研究業績

“MS”はムーンショット研究の成果

2024

Wada T, Takeda Y, Okekawa A, Komatsu G, Iwasa Y, Onogi Y, Takasaki I, Hamashima T, Sasahara M, Tsuneki H, Sasaoka T: Deletion of platelet-derived growth factor receptor β suppresses tumorigenesis in metabolic dysfunction-associated steatohepatitis (MASH) mice with diabetes. Sci Rep, 14(1):23829 (2024). MS
https://pubmed.ncbi.nlm.nih.gov/39394459/
Tanimura K, Saito S, Tsuda S, Ono Y, Deguchi M, Nagamatsu T, Fujii T, Nakatsuka M, Kobashi G, Arase H, Yamada H: Low-dose aspirin and heparin treatment improves pregnancy outcome in recurrent pregnancy loss women with anti-β2-glycoprotein I/HLA-DR autoantibodies: a prospective, multicenter, observational study. Front Immunol, 15:1445852 (2024). MS
https://pubmed.ncbi.nlm.nih.gov/39391301/
Saito S: Role of immune cells in the establishment of implantation and maintenance of pregnancy and immunomodulatory therapies for patients with repeated implantation failure and recurrent pregnancy loss. Reprod Med Biol, 23(1):e12600 (2024). MS
https://pubmed.ncbi.nlm.nih.gov/39091423/
Zhou Y, Takahashi JI, Sakurai H: New Directions for Advanced Targeting Strategies of EGFR Signaling in Cancer. Biol Pharm Bull, 47(5):895-903 (2024). MS
https://pubmed.ncbi.nlm.nih.gov/38692865/
Kado T, Nishimura A, Tobe K: History and future perspectives of adipose tissue macrophage biology. Front Pharmacol, 15:1373182 (2024). MS
https://pubmed.ncbi.nlm.nih.gov/38562458/
Nakashima A, Furuta A, Yoshida-Kawaguchi M, Yamada K, Nunomura H, Morita K, Yasuda I, Yoneda S, Yamaki-Ushijima A, Shima T, Tsuda S: Immunological regulation and the role of autophagy in preeclampsia. Am J Reprod Immunol, 91(3):e13835 (2024). MS
https://pubmed.ncbi.nlm.nih.gov/38467995/
Hayashi R, Hara A, Iwasa Y: Viral rebound occurrence immediately after drug discontinuation involving neither drug resistance nor latent reservoir. J Theor Biol, 582:111767 (2024). MS
https://pubmed.ncbi.nlm.nih.gov/38387506/
Yonezawa S, Haruki T, Koizumi K, Taketani A, Oshima Y, Oku M, Wada A, Sato T, Masuda N, Tahara J, Fujisawa N, Koshiyama S, Kadowaki M, Kitajima I, Saito S: Establishing Monoclonal Gammopathy of Undetermined Significance as an Independent Pre-Disease State of Multiple Myeloma Using Raman Spectroscopy, Dynamical Network Biomarker Theory, and Energy Landscape Analysis. Int J Mol Sci, 25(3):1570 (2024). MS
https://pubmed.ncbi.nlm.nih.gov/38338848/
Okekawa A, Wada T, Onogi Y, Takeda Y, Miyazawa Y, Sasahara M, Tsuneki H, Sasaoka T: Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity. Mol Med, 30(1):21 (2024). MS
https://pubmed.ncbi.nlm.nih.gov/38317079/
Tsuneki H, Honda K, Sekine Y, Yahata K, Yasue M, Fujishima M, Takeda R, Wada T, Sasaoka T: C-terminal peptide of preproorexin enhances brain-derived neurotrophic factor expression in rat cerebrocortical cells and recognition memory in mice. Eur J Pharmacol, 964:176306 (2024). MS
https://pubmed.ncbi.nlm.nih.gov/38145647/
Kikuchi S, Sugama Y, Takada K, Kamihara Y, Wada A, Arihara Y, Nakamura H, Sato T: Simultaneous XIAP and cIAP1/2 inhibition by a dimeric SMAC mimetic AZD5582 induces apoptosis in multiple myeloma. J Pharmacol Sci, 154(1):30-36 (2024). MS
https://pubmed.ncbi.nlm.nih.gov/38081681/
Oku M: Clarinet plots: Alternative to violin plots to display zero-inflated distribution of scRNA-seq data. IPSJ Trans Bioinform, 17:48-54 (2024). MS
https://doi.org/10.2197/ipsjtbio.17.48
Yonezawa S, Haruki T, Koizumi K, Watanabe T M, Abe K, Tada Y, Horita Y: Effects of pseudobulk and Gaussian noise on the application of the dynamical network biomarker theory to single-cell RNA-seq data. JASSE, 11(1):147-157 (2024). MS
https://doi.org/10.15748/jasse.11.147
Shen X, Sasahara H, Imura J, Oku M, Aihara K: Re-stabilizing large-scale network systems using high-dimension low-sample-size data analysis. IEEE Trans Emerg Top Comput Intell, : (2024). MS
https://doi.org/10.1109/TETCI.2024.3442824
Fujita H, Haruki T, Sudo K, Koga Y, Nakamura Y, Abe K, Yoshida Y, Koizumi K, Watanabe T M: Yuragi biomarker concept for evaluating human induced pluripotent stem cells using heterogeneity-based Raman finger-printing. Biophys Physicobiol, 21(Supplemental):e211016 (2024). MS
https://doi.org/10.2142/biophysico.bppb-v21.s016

2023

Tsuneki H, Sugiyama M, Sato K, Ito H, Nagai S, Kon K, Wada T, Kobayashi N, Okada T, Toyooka N, Kawasaki M, Ito T, Otsubo R, Okuzaki D, Yasui T, Sasaoka T: Resting phase-administration of lemborexant ameliorates sleep and glucose tolerance in type 2 diabetic mice. Eur J Pharmacol, 961:176190 (2023). MS
https://pubmed.ncbi.nlm.nih.gov/37952563/
Akagi K, Koizumi K, Kadowaki M, Kitajima I, Saito S: New Possibilities for Evaluating the Development of Age-Related Pathologies Using the Dynamical Network Biomarkers Theory. Cells, 12(18):2297 (2023). MS
https://pubmed.ncbi.nlm.nih.gov/37759519/
Kobayashi E, Kamihara Y, Arai M, Wada A, Kikuchi S, Hatano R, Iwao N, Susukida T, Ozawa T, Adachi Y, Kishi H, Dang NH, Yamada T, Hayakawa Y, Morimoto C, Sato T: Development of a Novel CD26-Targeted Chimeric Antigen Receptor T-Cell Therapy for CD26-Expressing T-Cell Malignancies. Cells, 12(16):2059 (2023). MS
https://pubmed.ncbi.nlm.nih.gov/37626869/
Saito S, Tsuda S, Nakashima A: T cell immunity and the etiology and pathogenesis of preeclampsia. J Reprod Immunol, 159:104125 (2023). MS
https://pubmed.ncbi.nlm.nih.gov/37573650/
Oshima Y, Haruki T, Koizumi K, Yonezawa S, Taketani A, Kadowaki M, Saito S: Practices, Potential, and Perspectives for Detecting Predisease Using Raman Spectroscopy. Int J Mol Sci, 24(15):12170 (2023). MS
https://pubmed.ncbi.nlm.nih.gov/37569541/
Kikuchi S, Wada A, Kamihara Y, Yamamoto I, Kirigaya D, Kunimoto K, Horaguchi R, Fujihira T, Nabe Y, Minemura T, Dang NH, Sato T: A Novel Mechanism for Bone Loss: Platelet Count Negatively Correlates with Bone Mineral Density via Megakaryocyte-Derived RANKL. Int J Mol Sci, 24(15):12150 (2023). MS
https://pubmed.ncbi.nlm.nih.gov/37569526/
Tanimura K, Saito S, Tsuda S, Ono Y, Ota H, Wada S, Deguchi M, Nakatsuka M, Nagamatsu T, Fujii T, Kobashi G, Arase H, Yamada H: Anti-β2-glycoprotein I/HLA-DR Antibody and Adverse Obstetric Outcomes. Int J Mol Sci, 24(13):10958 (2023). MS
https://pubmed.ncbi.nlm.nih.gov/37446134/
Karim M, Iqbal T, Nawaz A, Yaku K, Nakagawa T: Deletion of Nmnat1 in Skeletal Muscle Leads to the Reduction of NAD(+) Levels but Has No Impact on Skeletal Muscle Morphology and Fiber Types. J Nutr Sci Vitaminol (Tokyo), 69(3):184-189 (2023). MS
https://pubmed.ncbi.nlm.nih.gov/37394423/
Zhou Y, Oki R, Tanaka A, Song L, Takashima A, Hamada N, Yokoyama S, Yano S, Sakurai H: Cellular stress induces non-canonical activation of the receptor tyrosine kinase EphA2 through the p38-MK2-RSK signaling pathway. J Biol Chem, 299(5):104699 (2023). MS
https://pubmed.ncbi.nlm.nih.gov/37059179/
Kikuchi S, Wada A, Kamihara Y, Okazaki K, Jawaid P, Rehman MU, Kobayashi E, Susukida T, Minemura T, Nabe Y, Iwao N, Ozawa T, Hatano R, Yamada M, Kishi H, Matsuya Y, Mizuguchi M, Hayakawa Y, Dang NH, Sakamoto Y, Morimoto C, Sato T: DPP8 Selective Inhibitor Tominostat as a Novel and Broad-Spectrum Anticancer Agent against Hematological Malignancies. Cells, 12(7):1100 (2023). MS
https://pubmed.ncbi.nlm.nih.gov/37048172/
Jo M, Koizumi K, Suzuki M, Kanayama D, Watanabe Y, Gouda H, Mori H, Mizuguchi M, Obita T, Nabeshima Y, Toyooka N, Okada T: Design, synthesis, structure-activity relationship studies, and evaluation of novel GLS1 inhibitors. Bioorg Med Chem Lett, 87:129266 (2023). MS
https://pubmed.ncbi.nlm.nih.gov/37011768/
Nakashima A, Furuta A, Yamada K, Yoshida-Kawaguchi M, Yamaki-Ushijima A, Yasuda I, Ito M, Yamashita S, Tsuda S, Yoneda S, Cheng S, Sharma S, Shima T: The Role of Autophagy in the Female Reproduction System: For Beginners to Experts in This Field. Biology (Basel), 12(3):373 (2023). MS
https://pubmed.ncbi.nlm.nih.gov/36979065/
Omura M, Yagi K, Nagaoka R, Yoshida K, Yamaguchi T, Hasegawa H: Effect of Clutter Filter in High-Frame-Rate Ultrasonic Backscatter Coefficient Analysis. Sensors (Basel), 23(5):2639 (2023). MS
https://pubmed.ncbi.nlm.nih.gov/36904843/
Wada T, Miyazawa Y, Ikurumi M, Fuse K, Okekawa A, Onogi Y, Saito S, Tsuneki H, Sasaoka T: A transdermal treatment with MC903 ameliorates diet-induced obesity by reducing visceral fat and increasing myofiber thickness and energy consumption in mice. Nutr Metab (Lond), 20(1):10 (2023). MS
https://pubmed.ncbi.nlm.nih.gov/36774476/
Omura M, Yagi K, Nagaoka R, Hasegawa H: Contrast analysis in ultrafast ultrasound blood flow imaging of jugular vein. J Med Ultrason (2001), 50(2):131-141 (2023). MS
https://pubmed.ncbi.nlm.nih.gov/36757634/
Shen X, Sasahara H, Imura J, Oku M, Aihara K: Data-driven re-stabilization of gene regulatory network towards early medical treatment. IFAC-PapersOnLine, 56(2):6200-6205 (2023). MS
https://doi.org/10.1016/j.ifacol.2023.10.738
Yasukata H, Shen X, Sasahara H, Imura J, Oku M, Aihara K: Design of input assignment and feedback gain for re-stabilizing undirected networks with High-Dimension Low-Sample-Size data. Int J Robust Nonlinear Control, 33(12):6734-6753 (2023). MS
https://doi.org/10.1002/rnc.6720
Oku M: Estimation of the critical transition probability using quadratic polynomial approximation with skewness-based reject option. NOLTA, 14(2):242-253 (2023). MS
https://doi.org/10.1587/nolta.14.242
Shen X, Sasahara H, Morishita M, Imura J, Oku M, Aihara K: Model-free dominant pole placement for restabilizing high-dimensional network systems via small-sample-size data. IEEE Access, 11:45572-45585 (2023). MS
https://doi.org/10.1109/ACCESS.2023.3274530
Saito Y, Sasahara H, Shen X, Pena Ramirez J, Imura J, Oku M, Aihara K: Pre-disease detection using dynamical network biomarkers in gene regulatory networks with cell-to-cell interaction. IFAC-PapersOnLine, 56(2):6459-6464 (2023). MS
https://doi.org/10.1016/j.ifacol.2023.10.859
赤木一考, 小泉桂一, 森下正英, 沈迅, 井村順一, 奥牧人, 笹岡利安, 戸邉一之, 門脇真, 齋藤滋: 数理学と生物実験の連携によるメタボリックシンドロームの未病遺伝子の同定. 糖尿病・内分泌代謝科, 57(3):325-331 (2023). MS

2022

Suzuki Y, Munakata L, Omata D, Koizumi K, Suzuki R: Feasibility study of novel nanoparticles derived from Glycyrrhizae radix as vaccine adjuvant for cancer immunotherapy. Immunotherapy, 14(18):1443-1455 (2022). MS
https://pubmed.ncbi.nlm.nih.gov/36597713/
Kikuchi S, Wada A, Kamihara Y, Nabe Y, Minemura T, Murakami J, Dang NH, Sato T: Involvement of activation induced cytidine deaminase in malignant B-cells expressing two distinct M-components as an etiology of biclonal gammopathy. Medicine (Baltimore), 101(51):e32260 (2022). MS
https://pubmed.ncbi.nlm.nih.gov/36595774/
Haruki T, Yonezawa S, Koizumi K, Yoshida Y, Watanabe TM, Fujita H, Oshima Y, Oku M, Taketani A, Yamazaki M, Ichimura T, Kadowaki M, Kitajima I, Saito S: Application of the Dynamical Network Biomarker Theory to Raman Spectra. Biomolecules, 12(12):1730 (2022). MS
https://pubmed.ncbi.nlm.nih.gov/36551158/
Furuta A, Shima T, Yoshida-Kawaguchi M, Yamada K, Yasuda I, Tsuda S, Yamaki-Ushijima A, Yoneda S, Higashisaka K, Cheng SB, Matsumoto K, Tsutsumi Y, Sharma S, Saito S, Nakashima A: Chloroquine is a safe autophagy inhibitor for sustaining the expression of antioxidant enzymes in trophoblasts. J Reprod Immunol, 155:103766 (2022). MS
https://pubmed.ncbi.nlm.nih.gov/36470134/
Nawaz A, Bilal M, Fujisaka S, Kado T, Aslam MR, Ahmed S, Okabe K, Igarashi Y, Watanabe Y, Kuwano T, Tsuneyama K, Nishimura A, Nishida Y, Yamamoto S, Sasahara M, Imura J, Mori H, Matzuk MM, Kudo F, Manabe I, Uezumi A, Nakagawa T, Oishi Y, Tobe K: Depletion of CD206(+) M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration. Nat Commun, 13(1):7058 (2022). MS
https://pubmed.ncbi.nlm.nih.gov/36411280/
Tsuneki H, Sugiyama M, Ito T, Sato K, Matsuda H, Onishi K, Yubune K, Matsuoka Y, Nagai S, Yamagishi T, Maeda T, Honda K, Okekawa A, Watanabe S, Yaku K, Okuzaki D, Otsubo R, Nomoto M, Inokuchi K, Nakagawa T, Wada T, Yasui T, Sasaoka T: Food odor perception promotes systemic lipid utilization. Nat Metab, 4(11):1514-1531 (2022). MS
https://pubmed.ncbi.nlm.nih.gov/36376564/
Asaoka R, Kiyomatsu H, Miura H, Jono A, Kinoshita T, Takao M, Katagiri T, Oshima Y: Prognostic potential and pathological validation of a diagnostic application using Raman spectroscopy in the characterization of degenerative changes in the cartilage of the humeral head. J Biomed Opt, 27(11):115002 (2022). MS
https://pubmed.ncbi.nlm.nih.gov/36352498/
Iqbal T, Nawaz A, Karim M, Yaku K, Hikosaka K, Matsumoto M, Nakagawa T: Loss of hepatic Nmnat1 has no impact on diet-induced fatty liver disease. Biochem Biophys Res Commun, 636(Pt 1):89-95 (2022). MS
https://pubmed.ncbi.nlm.nih.gov/36332487/
Hayashi S, Muraleedharan CK, Oku M, Tomar S, Hogan SP, Quiros M, Parkos CA, Nusrat A: Intestinal epithelial BLT1 promotes mucosal repair. JCI Insight, 7(23):e162392 (2022). MS
https://pubmed.ncbi.nlm.nih.gov/36301666/
Tsuneki H, Maeda T, Takata S, Sugiyama M, Otsuka K, Ishizuka H, Onogi Y, Tokai E, Koshida C, Kon K, Takasaki I, Hamashima T, Sasahara M, Rudich A, Koya D, Sakurai T, Yanagisawa M, Yamanaka A, Wada T, Sasaoka T: Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity. Cell Rep, 41(3):111497 (2022). MS
https://pubmed.ncbi.nlm.nih.gov/36261021/
Saito S: Reconsideration of the Role of Regulatory T Cells during Pregnancy: Differential Characteristics of Regulatory T Cells between the Maternal-Fetal Interface and Peripheral Sites and between Early and Late Pregnancy. Med Princ Pract, 31(5):403-414 (2022). MS
https://pubmed.ncbi.nlm.nih.gov/36195068/
Morioka E, Kasuga Y, Kanda Y, Moritama S, Koizumi H, Yoshikawa T, Miura N, Ikeda M, Higashida H, Holmes TC, Ikeda M: Mitochondrial LETM1 drives ionic and molecular clock rhythms in circadian pacemaker neurons. Cell Rep, 39(6):110787 (2022). MS
https://pubmed.ncbi.nlm.nih.gov/35545046/
Okabe K, Yaku K, Uchida Y, Fukamizu Y, Sato T, Sakurai T, Tobe K, Nakagawa T: Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects. Front Nutr, 9:868640 (2022). MS
https://pubmed.ncbi.nlm.nih.gov/35479740/
Kadowaki M, Yamamoto T, Hayashi S: Neuro-immune crosstalk and food allergy: Focus on enteric neurons and mucosal mast cells. Allergol Int, 71(3):278-287 (2022). MS
https://pubmed.ncbi.nlm.nih.gov/35410807/
Takasaki I, Watanabe A, Okada T, Kanayama D, Nagashima R, Shudo M, Shimodaira A, Nunomura K, Lin B, Watanabe Y, Gouda H, Miyata A, Kurihara T, Toyooka N: Design and synthesis of pyrido[2,3-d]pyrimidine derivatives for a novel PAC1 receptor antagonist. Eur J Med Chem, 231:114160 (2022). MS
https://pubmed.ncbi.nlm.nih.gov/35124531/
Yonehara K, Zhou Y, Takahashi JI, Yokoyama S, Tomihara K, Noguchi M, Sakurai H: RSK-Mediated Non-canonical Activation of EphA2 by Tamoxifen. Biol Pharm Bull, 45(2):162-168 (2022). MS
https://pubmed.ncbi.nlm.nih.gov/35110502/
Kanauchi Y, Yamamoto T, Yoshida M, Zhang Y, Lee J, Hayashi S, Kadowaki M: Cholinergic anti-inflammatory pathway ameliorates murine experimental Th2-type colitis by suppressing the migration of plasmacytoid dendritic cells. Sci Rep, 12(1):54 (2022). MS
https://pubmed.ncbi.nlm.nih.gov/34997096/
Mozumi M, Nagaoka R, Hasegawa H: Improving image contrast and accuracy in velocity estimation by convolution filters for intracardiac blood flow imaging. Ultrasonics, 120:106650 (2022).
https://pubmed.ncbi.nlm.nih.gov/34871950/
Inujima A, Koizumi K, Shibahara N: Immunostimulatory properties of heat-resistant RNA in a decoction of Glycyrrhizae Radix. Biomed Pharmacother, 145:112457 (2022). MS
https://pubmed.ncbi.nlm.nih.gov/34864611/
Aihara K, Liu R, Koizumi K, Liu X, Chen L: Dynamical network biomarkers: Theory and applications. Gene, 808:145997 (2022). MS
https://pubmed.ncbi.nlm.nih.gov/34626720/
Omura M, Nagaoka R, Yagi K, Yoshida K, Yamaguchi T, Hasegawa H: Characterization of blood mimicking fluid with ultrafast ultrasonic and optical image velocimeters. Japanese Journal of Applied Physics, 61(SG):SG1067 (2022). MS
https://doi.org/10.35848/1347-4065/ac4ea9
Nagaoka R, Omura M, Mozumi M, Yagi K, Hasegawa H: Investigation on application of singular value decomposition filter in element domain for extraction of ultrasonic echoes from blood cells in jugular veins. Japanese Journal of Applied Physics, 61(SG):SG1011 (2022). MS
https://doi.org/10.35848/1347-4065/ac4680
Shen X, Morishita M, Imura J, Oku M, Aihara K: Low-Sample-Size Data-Driven Re-stabilization of Gene Network Systems. IFAC-PapersOnLine, 55(25):241-246 (2022). MS
https://doi.org/10.1016/j.ifacol.2022.09.353
Furuta A, Shima T, Kawaguchi M, Yamaki-Ushijima A, Yasuda I, Tsuda S, Yoneda S, Higashisaka K, Cheng S-B, Matsumoto K, Tsutsumi Y, Sharma S, Saito S, Nakashima A: The Autophagy-Lysosomal Machinery Enhances Cytotrophoblast-Syncytiotrophoblast Fusion Process. Reproductive Medicine, 3(2):112-126 (2022). MS
https://doi.org/10.3390/reprodmed3020010

2021

Nishida Y, Nawaz A, Hecht K, Tobe K: Astaxanthin as a Novel Mitochondrial Regulator: A New Aspect of Carotenoids, beyond Antioxidants. Nutrients, 14(1):107 (2021).
https://pubmed.ncbi.nlm.nih.gov/35010981/
Nawaz A, Nishida Y, Takikawa A, Fujisaka S, Kado T, Aminuddin A, Bilal M, Jeelani I, Aslam MR, Nishimura A, Kuwano T, Watanabe Y, Igarashi Y, Okabe K, Ahmed S, Manzoor A, Usui I, Yagi K, Nakagawa T, Tobe K: Astaxanthin, a Marine Carotenoid, Maintains the Tolerance and Integrity of Adipose Tissue and Contributes to Its Healthy Functions. Nutrients, 13(12):4374 (2021).
https://pubmed.ncbi.nlm.nih.gov/34959926/
Tsuji Y, Numajiri M, Ogami C, Kurosaki F, Miyamoto A, Aoyama T, Kawasuji H, Nagaoka K, Matsumoto Y, To H, Yamamoto Y: Development of a simple method for measuring tedizolid concentration in human serum using HPLC with a fluorescent detector. Medicine (Baltimore), 100(49):e28127 (2021).
https://pubmed.ncbi.nlm.nih.gov/34889275/
Chujo D, Kawabe A, Matsushita M, Tsutsumi C, Haseda F, Imagawa A, Hanafusa T, Ueki K, Kajio H, Yagi K, Tobe K, Shimoda M: Fulminant type 1 diabetes patients display high frequencies of IGRP-specific type 1 CD8⁺ T cells. Clin Immunol, 233:108893 (2021).
https://pubmed.ncbi.nlm.nih.gov/34808330/
Yaku K, Palikhe S, Izumi H, Yoshida T, Hikosaka K, Hayat F, Karim M, Iqbal T, Nitta Y, Sato A, Migaud ME, Ishihara K, Mori H, Nakagawa T: BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities. Nat Commun, 12(1):6767 (2021). MS
https://pubmed.ncbi.nlm.nih.gov/34799586/
Yamada M, Sekine M, Tatsuse T: Pathological gaming and its association with lifestyle, irritability, and school and family environments among Japanese elementary school children. J Epidemiol, 33(7):335-341 (2021).
https://pubmed.ncbi.nlm.nih.gov/34744101/
Yokoyama S, Takahashi A, Kikuchi R, Nishibu S, Lo JA, Hejna M, Moon WM, Kato S, Zhou Y, Hodi FS, Song JS, Sakurai H, Fisher DE, Hayakawa Y: SOX10 Regulates Melanoma Immunogenicity through an IRF4-IRF1 Axis. Cancer Res, 81(24):6131-6141 (2021).
https://pubmed.ncbi.nlm.nih.gov/34728538/
Haryuni RD, Tanaka T, Takahashi JI, Onuma I, Zhou Y, Yokoyama S, Sakurai H: Temozolomide Induces Endocytosis of EGFRvIII via p38-Mediated Non-canonical Phosphorylation in Glioblastoma Cells. Biol Pharm Bull, 44(11):1681-1687 (2021). MS
https://pubmed.ncbi.nlm.nih.gov/34719645/
Nakahori N, Sekine M, Yamada M, Tatsuse T, Kido H, Suzuki M: Future projections of the prevalence of dementia in Japan: results from the Toyama Dementia Survey. BMC Geriatr, 21(1):602 (2021).
https://pubmed.ncbi.nlm.nih.gov/34702187/
Nose S, Sekine M, Tatsuse T, Yamada M: Work and family characteristics as socioeconomic determinants in long sickness absence: the Japanese civil servants study. Ind Health, 60(2):164-175 (2021).
https://pubmed.ncbi.nlm.nih.gov/34657893/
Maegawa H, Tobe K, Nakamura I, Uno S: Real-world evidence for long-term safety and effectiveness of ipragliflozin in treatment-naïve versus non-naïve Japanese patients with type 2 diabetes mellitus: subgroup analysis of a 3-year post-marketing surveillance study (STELLA-LONG TERM). Diabetol Int, 12(4):430-444 (2021).
https://pubmed.ncbi.nlm.nih.gov/34567926/
Bilal M, Nawaz A, Kado T, Aslam MR, Igarashi Y, Nishimura A, Watanabe Y, Kuwano T, Liu J, Miwa H, Era T, Ikuta K, Imura J, Yagi K, Nakagawa T, Fujisaka S, Tobe K: Fate of adipocyte progenitors during adipogenesis in mice fed a high-fat diet. Mol Metab, 54:101328 (2021). MS
https://pubmed.ncbi.nlm.nih.gov/34562641/
Kawataka M, Kido T, Tsuda R, Onose T, Asano R, Yamazaki M, Sugishita N, Hounoki H, Kakiuchi T, Shinoda K, Tobe K: A Case of Granulomatosis with Polyangiitis with Various Breast Lesions as the Initial Symptoms: A Case-Based Review. Case Rep Rheumatol, 2021:4416072 (2021).
https://pubmed.ncbi.nlm.nih.gov/34545315/
Nakamura I, Maegawa H, Tobe K, Uno S: Correction to: Safety and Effectiveness of Ipragliflozin in Elderly Versus Non-elderly Japanese Patients with Type 2 Diabetes: Subgroup Analysis of STELLA-LONG TERM. Diabetes Ther, 12(10):2801-2805 (2021).
https://pubmed.ncbi.nlm.nih.gov/34463953/
Kido T, Shinoda K, Tobe K: A Case of Pulmonary Infarction Resembling Pneumonia during Immunosuppressive Treatment for Rheumatoid Arthritis. Case Rep Rheumatol, 2021:5983580 (2021).
https://pubmed.ncbi.nlm.nih.gov/34457368/
Tatsuse T, Sekine M, Yamada M, Cable N, Chandola T, Marmot MG: The Role of Facets of Job Satisfaction in the National and Socioeconomic Differences in Overall Job Satisfaction: A Comparison Between Studies of Civil Servants in Great Britain and Japan. J Occup Environ Med, 63(8):679-685 (2021).
https://pubmed.ncbi.nlm.nih.gov/34397660/
Koh G, Sekine M, Yamada M, Fujimura Y, Tatsuse T: Neighbourhood walkability and obesity among adults in rural Japan: results from a Japanese health database. J Public Health (Oxf), 44(4):e467-e474 (2021).
https://pubmed.ncbi.nlm.nih.gov/34387690/
Cheng S, Banerjee S, Daiello LA, Nakashima A, Jash S, Huang Z, Drake JD, Ernerudh J, Berg G, Padbury J, Saito S, Ott BR, Sharma S: Novel blood test for early biomarkers of preeclampsia and Alzheimer’s disease. Sci Rep, 11(1):15934 (2021).
https://pubmed.ncbi.nlm.nih.gov/34354200/
Shinoda K, Hamaguchi Y, Tobe K: Widespread Mechanic’s Hands in Antisynthetase Syndrome With Anti-OJ Antibody. J Rheumatol, 48(8):1341 (2021).
https://pubmed.ncbi.nlm.nih.gov/34329180/
Ikki Y, Yamada M, Sekine M: Regional disparity of certified teaching hospitals on physicians’ workload and wages, and popularity among medical students in Japan. Environ Health Prev Med, 26(1):75 (2021).
https://pubmed.ncbi.nlm.nih.gov/34284716/
Nakamura I, Maegawa H, Tobe K, Uno S: Correction to: Safety and Effectiveness of Ipragliflozin for Type 2 Diabetes in Japan: 12-Month Interim Results of the STELLA-LONG TERM Post-Marketing Surveillance Study. Adv Ther, 38(8):4599-4601 (2021).
https://pubmed.ncbi.nlm.nih.gov/34279807/
Zhang Y, Yamamoto T, Hayashi S, Kadowaki M: Suppression of plasmacytoid dendritic cell migration to colonic isolated lymphoid follicles abrogates the development of colitis. Biomed Pharmacother, 141:111881 (2021).
https://pubmed.ncbi.nlm.nih.gov/34246191/
Yashiro T, Ogata H, Zaidi SF, Lee J, Hayashi S, Yamamoto T, Kadowaki M: Pathophysiological Roles of Neuro-Immune Interactions between Enteric Neurons and Mucosal Mast Cells in the Gut of Food Allergy Mice. Cells, 10(7):1586 (2021).
https://pubmed.ncbi.nlm.nih.gov/34201851/
Yamaguchi S, Hamana H, Shitaoka K, Sukegawa K, Nagata T, Hayee A, Kobayashi E, Ozawa T, Fujii T, Muraguchi A, Tobe K, Kishi H: TCR function analysis using a novel system reveals the multiple unconventional tumor-reactive T cells in human breast cancer-infiltrating lymphocytes. Eur J Immunol, 51(9):2306-2316 (2021).
https://pubmed.ncbi.nlm.nih.gov/34171120/
Honoki H, Yagi K, Tsuda S, Wada T, Enkaku A, Nakagawa-Yokoyama M, Kamigishi M, Shikata M, Takikawa-Nishiday A, Fujisaka S, Chujo D, Sasaoka T, Nakashima A, Saito S, Tobe K: Type 1 diabetes woman with repeated miscarriages successfully gave birth after introducing an insulin pump with a predictive low glucose suspend feature. Diabetol Int, 12(3):324-329 (2021).
https://pubmed.ncbi.nlm.nih.gov/34150440/
Nakahori N, Sekine M, Yamada M, Tatsuse T, Kido H, Suzuki M: Association between marital status and cognitive function in Japan: results from the Toyama Dementia Survey. Psychogeriatrics, 21(4):627-635 (2021).
https://pubmed.ncbi.nlm.nih.gov/34034362/
Nakamura I, Maegawa H, Tobe K, Uno S: Correction to: Safety and Effectiveness of Ipragliflozin in Elderly Versus Non-elderly Japanese Patients with Type 2 Diabetes: Subgroup Analysis of STELLA-LONG TERM. Diabetes Ther, 12(6):1765-1768 (2021).
https://pubmed.ncbi.nlm.nih.gov/34018149/
Watanabe Y, Fujisaka S, Ikeda K, Ishikawa M, Yamada T, Nawaz A, Kado T, Kuwano T, Nishimura A, Bilal M, Liu J, Yagi K, Hase K, Tobe K: Gut microbiota, determined by dietary nutrients, drive modification of the plasma lipid profile and insulin resistance. iScience, 24(5):102445 (2021).
https://pubmed.ncbi.nlm.nih.gov/33997711/
Koizumi K, Oku M, Hayashi S, Inujima A, Shibahara N, Chen L, Igarashi Y, Tobe K, Saito S, Kadowaki M, Aihara K: Corrigendum to “Suppression of Dynamical Network Biomarker Signals at the Predisease State (Mibyou) before Metabolic Syndrome in Mice by a Traditional Japanese Medicine (Kampo Formula) Bofutsushosan”. Evid Based Complement Alternat Med, 2021:9760307 (2021).
https://pubmed.ncbi.nlm.nih.gov/33981354/
Ogami C, Tsuji Y, Seki H, Kawano H, To H, Matsumoto Y, Hosono H: An artificial neural network-pharmacokinetic model and its interpretation using Shapley additive explanations. CPT Pharmacometrics Syst Pharmacol, 10(7):760-768 (2021).
https://pubmed.ncbi.nlm.nih.gov/33955705/
Hayashi K, Tokui K, Inomata M, Azechi K, Mizushima I, Takata N, Taka C, Okazawa S, Kambara K, Imanishi S, Miwa T, Hayashi R, Matsui S, Nomura S, Tobe K: Case Series of Pleomorphic Carcinoma of the Lung Treated With Immune Checkpoint Inhibitors. In Vivo, 35(3):1687-1692 (2021).
https://pubmed.ncbi.nlm.nih.gov/33910853/
Yagi K, Imamura T, Tada H, Chujo D, Liu J, Shima Y, Ohbatake A, Miyamoto Y, Okazaki S, Ito N, Nakano K, Shikata M, Enkaku A, Takikawa A, Honoki H, Fujisaka S, Origasa H, Tobe K: Diastolic Cardiac Function Improvement by Liraglutide Is Mainly Body Weight Reduction Dependent but Independently Contributes to B-Type Natriuretic Peptide Reduction in Patients with Type 2 Diabetes with Preserved Ejection Fraction. J Diabetes Res, 2021:8838026 (2021).
https://pubmed.ncbi.nlm.nih.gov/33855087/
Nakahori N, Sekine M, Tatsuse T, Yamada M: Effect modification by workplace social capital on the association between depression and workplace and family stress: the Japanese civil servant study. BMC Public Health, 21(1):726 (2021).
https://pubmed.ncbi.nlm.nih.gov/33853551/
Ogawa K, Oshima Y, Etoh T, Kaisyakuji Y, Tojigamori M, Ohno Y, Shiraishi N, Inomata M: Label-free detection of human enteric nerve system using Raman spectroscopy: A pilot study for diagnosis of Hirschsprung disease. J Pediatr Surg, 56(7):1150-1156 (2021).
https://pubmed.ncbi.nlm.nih.gov/33838894/
Tobe K, Maegawa H, Nakamura I, Uno S: Effect of ipragliflozin on liver function in Japanese type 2 diabetes mellitus patients: subgroup analysis of a 3-year post-marketing surveillance study (STELLA-LONG TERM). Endocr J, 68(8):905-918 (2021).
https://pubmed.ncbi.nlm.nih.gov/33827996/
Tobe K, Maegawa H, Nakamura I, Uno S: Safety and effectiveness of ipragliflozin in Japanese patients with type 2 diabetes mellitus and impaired renal function: subgroup analysis of a 3-year post-marketing surveillance study (STELLA-LONG TERM). Diabetol Int, 12(2):181-196 (2021).
https://pubmed.ncbi.nlm.nih.gov/33786273/
Kuwano T, Izumi H, Aslam MR, Igarashi Y, Bilal M, Nishimura A, Watanabe Y, Nawaz A, Kado T, Ikuta K, Yamamoto S, Sasahara M, Fujisaka S, Yagi K, Mori H, Tobe K: Generation and characterization of a Meflin-CreERT2 transgenic line for lineage tracing in white adipose tissue. PLoS One, 16(3):e0248267 (2021).
https://pubmed.ncbi.nlm.nih.gov/33760832/
Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Nakashima S, Shiroshima T, Maeda A, Iwasawa-Okamoto S, Azechi K, Osaka F, Saitoh T, Maenaka K, Shimada T, Fukata Y, Fukata M, Matsumoto J, Nishijo H, Takao K, Tanaka S, Okabe S, Tabuchi K, Uemura T, Mishina M, Mori H, Fukai S: Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice. Nat Commun, 12(1):1848 (2021).
https://pubmed.ncbi.nlm.nih.gov/33758193/
Nakamura I, Maegawa H, Tobe K, Uno S: Safety and Effectiveness of Ipragliflozin in Elderly Versus Non-elderly Japanese Patients with Type 2 Diabetes: Subgroup Analysis of STELLA-LONG TERM. Diabetes Ther, 12(5):1359-1378 (2021).
https://pubmed.ncbi.nlm.nih.gov/33730336/
Ohkuchi A, Saito S, Yamamoto T, Minakami H, Masuyama H, Kumasawa K, Yoshimatsu J, Nagamatsu T, Dietl A, Grill S, Hund M: Short-term prediction of preeclampsia using the sFlt-1/PlGF ratio: a subanalysis of pregnant Japanese women from the PROGNOSIS Asia study. Hypertens Res, 44(7):813-821 (2021).
https://pubmed.ncbi.nlm.nih.gov/33727707/
Takahashi S, Tsuji Y, Kasai H, Ogami C, Kawasuji H, Yamamoto Y, To H: Classification Tree Analysis Based On Machine Learning for Predicting Linezolid-Induced Thrombocytopenia. J Pharm Sci, 110(5):2295-2300 (2021).
https://pubmed.ncbi.nlm.nih.gov/33609520/
Imamura M, Takahashi A, Matsunami M, Horikoshi M, Iwata M, Araki SI, Toyoda M, Susarla G, Ahn J, Park KH, Kong J, Moon S, Sobrin L, Yamauchi T, Tobe K, Maegawa H, Kadowaki T, Maeda S: Genome-wide association studies identify two novel loci conferring susceptibility to diabetic retinopathy in Japanese patients with type 2 diabetes. Hum Mol Genet, 30(8):716-726 (2021).
https://pubmed.ncbi.nlm.nih.gov/33607655/
Ohkuchi A, Masuyama H, Yamamoto T, Kikuchi T, Taguchi N, Wolf C, Saito S: Economic evaluation of the sFlt-1/PlGF ratio for the short-term prediction of preeclampsia in a Japanese cohort of the PROGNOSIS Asia study. Hypertens Res, 44(7):822-829 (2021).
https://pubmed.ncbi.nlm.nih.gov/33594274/
Yagi K, Nagata Y, Yamagami T, Chujo D, Kamigishi M, Yokoyama-Nakagawa M, Shikata M, Enkaku A, Takikawa-Nishida A, Honoki H, Fujisaka S, Origasa H, Tobe K: High prevalence of fragmented QRS on electrocardiography in Japanese patients with diabetes irrespective of metabolic syndrome. J Diabetes Investig, 12(9):1680-1688 (2021).
https://pubmed.ncbi.nlm.nih.gov/33567117/
Sawa S, Sekine M, Yamada M: Social and Family Factors as Determinants of Sleep Habits in Japanese Elementary School Children: A Cross-Sectional Study from the Super Shokuiku School Project. Children (Basel), 8(2):110 (2021).
https://pubmed.ncbi.nlm.nih.gov/33562621/
Hounoki H, Shinoda K, Matsui A, Okumura M, Yamaguchi S, Kakeshita K, Yamazaki H, Koike T, Makino T, Tobe K: A Case of Systemic Lupus Erythematosus and Antineutrophil Cytoplasmic Antibodies-Associated Vasculitis Overlap Syndrome. Case Rep Rheumatol, 2021:6690658 (2021).
https://pubmed.ncbi.nlm.nih.gov/33505756/
Ono Y, Yoshino O, Hiraoka T, Sato E, Furue A, Nawaz A, Hatta H, Fukushi Y, Wada S, Tobe K, Hirota Y, Osuga Y, Unno N, Saito S: CD206+ macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model. Sci Rep, 11(1):853 (2021).
https://pubmed.ncbi.nlm.nih.gov/33441630/
Yamada M, Sekine M, Tatsuse T, Fujimura Y: Lifestyle, psychological stress, and incidence of adolescent constipation: results from the Toyama birth cohort study. BMC Public Health, 21(1):47 (2021).
https://pubmed.ncbi.nlm.nih.gov/33407297/
Asano R, Shinoda K, Tsuda R, Hounoki H, Kawataka M, Makino T, Imura J, Hamaguchi Y, Tobe K: Anti-TIF1γ antibody-positive dermatomyositis in a 15-year-old boy with Epstein-Barr virus-related nasopharyngeal cancer receiving nivolumab. Rheumatology (Oxford), 60(6):e197-e199 (2021).
https://pubmed.ncbi.nlm.nih.gov/33367923/
Tsuda R, Shinoda K, Ushijima R, Nakamura M, Katoh N, Imura J, Tobe K: A case of wild-type transthyretin cardiac amyloidosis with rheumatoid arthritis. Mod Rheumatol Case Rep, 5(2):206-213 (2021).
https://pubmed.ncbi.nlm.nih.gov/33314981/
Nakamura I, Maegawa H, Tobe K, Uno S: Real-World Evidence for Long-Term Safety and Effectiveness of Ipragliflozin in Japanese Patients with Type 2 Diabetes Mellitus: final Results of a 3-Year Post-Marketing Surveillance Study (STELLA-LONG TERM). Expert Opin Pharmacother, 22(3):373-387 (2021).
https://pubmed.ncbi.nlm.nih.gov/33012212/
Ogami C, Tsuji Y, Nishi Y, Kawasuji H, To H, Yamamoto Y: External Evaluation of Population Pharmacokinetics and Pharmacodynamics in Linezolid-Induced Thrombocytopenia: The Transferability of Published Models to Different Hospitalized Patients. Ther Drug Monit, 43(2):271-278 (2021).
https://pubmed.ncbi.nlm.nih.gov/33009290/
Nishi Y, Ogami C, Tsuji Y, Kawasuji H, Yamada H, Kawai S, Sakamaki I, To H, Yamamoto Y: Evaluation of the relationship between linezolid exposure and hyponatremia. J Infect Chemother, 27(2):165-171 (2021).
https://pubmed.ncbi.nlm.nih.gov/32933858/
Yamada M, Sekine M, Tatsuse T, Asaka Y: Prevalence and Associated Factors of Pathological Internet Use and Online Risky Behaviors Among Japanese Elementary School Children. J Epidemiol, 31(10):537-544 (2021).
https://pubmed.ncbi.nlm.nih.gov/32779630/
Wang X, Yamamoto T, Kadowaki M, Yang Y: Identification of key pathways and gene expression in the activation of mast cells via calcium flux using bioinformatics analysis. Biocell, 45(2):395-415 (2021).
https://doi.org/10.32604/biocell.2021.012280
Mozumi M, Omura M, Nagaoka R, Cinthio M, Hasegawa H: Impact of spacing of ultrasound receiving beams on estimation of 2D motion velocity. Japanese Journal of Applied Physics, 60(SD):SDDE07 (2021).
https://doi.org/10.35848/1347-4065/abeac0
Hasegawa H, Mozumi M, Omura M, Nagaoka R: Improvement of spatial resolution of medical ultrasound images by constrained least-square method. Japanese Journal of Applied Physics, 60(SD):SDDE16 (2021).
https://doi.org/10.35848/1347-4065/abf3a1
Nagata K, Nagaoka R, Wilhjelm J E, Hasegawa H: Study on estimation of surface roughness by separation of reflection and backscattering components using ultrasonic synthetic aperture imaging. Japanese Journal of Applied Physics, 60(SD):SDDE09 (2021).
https://doi.org/10.35848/1347-4065/abf2a4
関根道和: 【大学から公衆衛生の魅力を発信する】ビッグデータ時代の公衆衛生富山大学地域連携推進機構地域医療保健支援部門の取組み. 北陸と公衆衛生, (67):6-8 (2021).
藤本孝子, 関根道和, 山田正明: 中学生のインターネット依存と疲労自覚症状及び学校・家庭生活や食・生活習慣との関連富山県内某中学校生徒を対象とした横断的研究. 北陸公衆衛生学会誌, 47(2):36-45 (2021).

2020

Koizumi K, Oku M, Hayashi S, Inujima A, Shibahara N, Chen L, Igarashi Y, Tobe K, Saito S, Kadowaki M, Aihara K: Suppression of Dynamical Network Biomarker Signals at the Predisease State (Mibyou) before Metabolic Syndrome in Mice by a Traditional Japanese Medicine (Kampo Formula) Bofutsushosan. Evid Based Complement Alternat Med, 2020:9129134 (2020).
https://pubmed.ncbi.nlm.nih.gov/32831883/
Nagaoka R, Wilhjelm JE, Hasegawa H: Preliminary study on the separation of specular reflection and backscattering components using synthetic aperture beamforming. J Med Ultrason (2001), 47(4):493-500 (2020).
https://pubmed.ncbi.nlm.nih.gov/32749560/